Richa Madaan

Richa Madaan

Research Peptides Focused on Reproductive Health and Libido

  Jan 17, 2024

Researchers interested in learning more about peptide studies within the context of erectile dysfunction, libido, and sexual health may be curious about the more widely researched compounds within this focus. 

Certain research peptides have exhibited potential impacts and are continuously studied for the possible actions listed below:

  • Potential increase in blood flow
  • Potential for heightened concentrations of testosterone production
  • Potential for increased hormonal regulation and stability

We have compiled this reference article to review certain research peptides studied within this context. 

PT-141 Peptide

PT-141, also known as Bremelanotide, is a synthetic agonist of the melanocortin receptors in the brain, which is believed to affect carnal arousal, hunger, and metabolism. 

This peptide has been explored in research studies for its potential impact on hypoactive sexual desire disorder (HSDD) in premenopausal females in research models.

Fact: The success of Peptides is 42%.

Despite its initial focus on female impacts, research has suggested that PT-141 may potentially dramatically increase male libido and possibly extend the duration of erection. 

Scientists observed that research models formerly unresponsive to PDE5 inhibitors exhibited positive responses when exposed to PT-141.

Melanotan II Peptide

Another synthetic melanocortin receptor agonist that may engage in interaction with the melanocortin system is Melanotan II. One of its active metabolites is designated as PT-141. 

Studies suggest that Melanotan II primary potential action is in increasing pigmentation in skin without exposure to UV (sunless tanning). 

Nevertheless, research purports it may also enhance arousal and elevated duration in male research models of erectile dysfunction (ED), regardless of even if the ED is psychogenic or organic. 

Oxytocin Peptide

Oxytocin is a hormone that may be found in naturally occurring quantities. The peptide has been posited by researchers to increase the intensity of libido, bonding, and extended periods of arousal. 

How Exactly Do Peptides Work for Libido and Erectile Dysfunction? 

Peptides have recently been identified as a potentially fruitful field of study within the context of erectile dysfunction (ED) research and reproductive health. 

Professionals speculate that both PT-141 and Melanotan II may exhibit some efficacy in mitigating symptoms associated with erectile dysfunction (ED), possibly via the activation of melanocortin receptors. 

Both substances are posited to stimulate the melanocortin receptors 3 and 4 in the brain, which are the receptors related to an increased desire to engage in carnal activity. 

It is also possible that activating them may cause an increase in the synthesis of vasodilators (nitric oxide) in the penis, which may result in an erection.

Oxytocin is believed to operate by activating the appropriate oxytocin receptors, which might increase the intensity of hormonal release, and increase upright function. 

Statistics on Peptides: Back in 2017, the global market value of collagen peptides was estimated to be worth 720.3 million U.S. dollars.

Findings imply that it may also assist proper carnal function and erections in males by improving hormonal balance and increasing testosterone levels. This may be the case with some peptides. The following are some examples of possible outcomes:

A high percentage of body fat may result in cardiovascular issues and an increase in the aromatization of testosterone (T) into estrogen, eventually decreasing T synthesis. 

Research suggests that Tirzepatide and other weight research peptides may inhibit aromatization while reducing fat storage.

Some endocrine conditions may impair the function of the hypothalamic-pituitary-gonadal (HPG) axis, which may potentially result in low T and erectile dysfunction (ED). 

It has been purported that peptides such as Kisspeptin-10 may have the potential to directly activate the function of the HPG-axis and boost testosterone levels, both of which contribute to an improvement in upright functions.

Do You Know?: Kisspeptin is considered important in female sexual behavior, because of its ability to result in better treatments for women with low sexual desire.

Peptides and Sexual Health? 

The alleged efficacy of it for sexual health as an aid in enhancing both erectile function and arousal has been suggested by a significant body of clinical research. 

One phase-2A trial using PT-141, for instance, speculated that the peptide might induce a considerable increase in the duration of erections. The study involved 73 male subjects, some of whom were healthy and others who had impotence.

Click here to be redirected to Biotech Peptides’ website, where you can learn more about peptides, what they are, how they work, and what additional properties they may possess.


[i] Edinoff, A. N., Sanders, N. M., Lewis, K. B., Apgar, T. L., Cornett, E. M., Kaye, A. M., & Kaye, A. D. (2022). Bremelanotide for Treatment of Female Hypoactive Sexual Desire. Neurology International, 14(1), 75–88.

[ii] Molinoff, P. B., Shadiack, A. M., Earle, D., Diamond, L. E., & Quon, C. Y. (2003). PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Annals of the New York Academy of Sciences, 994, 96–102. 6632.2003.tb03167.x

[iii] Safarinejad, M. R., & Hosseini, S. Y. (2008). Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo-controlled study. The Journal of Urology, 179(3), 1066–1071.

[iv] Wessells, H., Levine, N., Hadley, M. E., Dorr, R., & Hruby, V. (2000). Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. International journal of impotence research, 12 Suppl 4, S74–S79.

[v] MacDonald, K., & Feifel, D. (2012). Dramatic improvement in sexual function induced by intranasal oxytocin. The journal of sexual medicine, 9(5), 1407–1410. 6109.2012.02703.x

[vi] Wang, L., Wang, N., Zhang, W., Cheng, X., Yan, Z., Shao, G., Wang, X., Wang, R., & Fu, C. (2022). Therapeutic peptides: current applications and future directions. Signal transduction and targeted therapy, 7(1), 48. 00904-4

[vii] Lee, A. C., Harris, J. L., Khanna, K. K., & Hong, J. H. (2019). A Comprehensive Review on Current Advances in Peptide Drug Development and Design. International journal of molecular sciences, 20(10), 2383.
[viii] Melis, M. R., & Argiolas, A. (2021). Oxytocin, Erectile Function, and Sexual Behavior: Last Discoveries and Possible Advances. International journal of molecular sciences, 22(19), 10376.